The enzyme L-asparaginase is of cardinal importance in the treatment of acute lymphatic leukaemia (ALL) in children and adults.
The principle of asparaginase therapy is the enzymatic cleavage of the amino acid asparagine into aspartic acid and ammonia, with consequent depletion of asparagine levels in the plasma and cerebrospinal fluid (see also test principle, page 2).
The test kit can be used to measure asparaginase activity during the course of therapy, with the purpose of ensuring that the asparaginase therapy is as good as possible.